Discussion: Alterations in Cellular ProcessesPhoto Credit: Getty ImagesAt its core, pathology is the study of disease. Diseases occur for many reasons. But some, such as cystic fibrosis and Parkinson’s Disease, occur because of alterations that prevent cells from functioning normally.Understanding of signals and symptoms of alterations in cellular processes is a critical step in diagnosis and treatment of many diseases. For the Advanced Practice Registered Nurse (APRN), this understanding can also help educate patients and guide them through their treatment plans.For this Discussion, you examine a case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts.To prepare:By Day 1 of this week, you will be assigned to a specific scenario for this Discussion. Please see the “Course Announcements” section of the classroom for your assignment from your Instructor.By Day 3 of Week 1Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:The role genetics plays in the disease.Why the patient is presenting with the specific symptoms described.The physiologic response to the stimulus presented in the scenario and why you think this response occurred.The cells that are involved in this process.How another characteristic (e.g., gender, genetics) would change your response.Week 1: Cellular Processes and the Genetic EnvironmentOne of the more common biology analogies refers to cells as the “building blocks” of life. This rightfully places an emphasis on understanding cells, cellular behavior, and the impact of the environment in which they function.Such an understanding helps explain how healthy cell activity contributes to good health. Just as importantly, it helps explain how breakdowns in cellular behavior and alterations to cells lead to health issues.This week, you examine cellular processes that are subject to alterations that can lead to disease. You evaluate the genetic environments within which these processes exist as well as the impact these environments have on disease.Learning ObjectivesStudents will:Evaluate cellular processes and alterations within cellular processesEvaluate the impact of the genetic environment on diseaseLearning ResourcesRequired Readings (click to expand/reduce)McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.Chapter 1: Cellular Biology; Summary ReviewChapter 2: Altered Cellular and Tissue Biology: Environmental Agents (pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary ReviewChapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and BasesChapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary ReviewChapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary ReviewChapter 7: Innate Immunity: Inflammation and Wound HealingChapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary ReviewChapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary ReviewChapter 10: Infection (pp. 289–303; stop at Infectious parasites and protozoans); (start at HIV); Summary ReviewChapter 11: Stress and Disease (stop at Stress, illness & coping); Summary ReviewChapter 12: Cancer Biology (stop at Resistance to destruction); Summary ReviewChapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary ReviewJustiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat PearlsRequired Media (click to expand/reduce)Module 1 Overview with Dr. Tara HarrisDr. Tara Harris reviews the structure of Module 1 as well as the expectations for the module. Consider how you will manage your time as you review your media and Learning Resources throughout the module to prepare for your Discussion and Assignment. (4m)Accessible player –Downloads–Download Video w/CCDownload AudioDownload TranscriptImmunity and InflammationKhan Academy (2010, February 24). Inflammatory response | Human anatomy and physiology | Health & medicine [Video file]. Retrieved from https://www.youtube.com/watch?v=FXSuEIMrPQkNote: The approximate length of the media program is 14 minutes.Soo, P. (2018, July 28). Pathophysiology Ch 10 alterations in immune function [Video file]. Retrieved from https://www.youtube.com/watch?v=Jz0wx1-jTdsNote: The approximate length of the media program is 37 minutes.Acid-Base Balance #1MedCram. (2012, April 28). Medical acid base balance, disorders & ABGs explained clearly [Video file]. Retrieved from https://www.youtube.com/watch?v=4wMEMhvrQxENote: The approximate length of the media program is 13 minutes.Acid-Base Balance #2MedCram. (2012, April 29). Medical acid base balance, disorders & ABGs explained clearly | 2 of 8 [Video file]. Retrieved from https://www.youtube.com/watch?v=GmEeKVTpOKINote: The approximate length of the media program is 15 minutes.HyponatremiaMedCram. (2017, December 23). Hyponatremia explained clearly (remastered) – Electrolyte imbalances [Video file]. Retrieved from https://www.youtube.com/watch?v=bLajK5Vy55MNote: The approximate length of the media program is 15 minutes.Online Media from Pathophysiology: The Biologic Basis for Disease in Adults and ChildrenIn addition to this week’s media, it is highly recommended that you access and view the resources included with the course text, Pathophysiology: The Biologic Basis for Disease in Adults and Children. Focus on the videos and animations in Chapters 3, 7, and 8 that relate to alterations in immunity, hyponatremia, and acid/base balance.3 resources for this discussion
